I built The Recordati Rare Diseases website with WordPress using a completely custom theme based on my custom starter theme. It is fully responsive, featuring a variety of custom templates. On the backend it uses ACF, site-specific widgets, and a couple of hand-built plugins.
I chose a Custom Post Type for the products featured throughout the site so the client can update branding information and links in one place and have the changes take affect site-wide.
The static pages all feature customizable sidebars, allowing the client to add any links they desire on a per-page basis.
A fully responsive site is always mandatory. Overall, the content was fairly simple and translated well to mobile. Some areas required special attention, like the products slider on the homepage that shows a different number of products at once depending on the screen size.